Crystal structure of 2[2'/-cyclohexyl]ethyl benzimidazole, C15H20N2
نویسندگان
چکیده
منابع مشابه
Crystal structure of 2-dibenzoylmethyl benzimidazole.
treatment of various infections caused by fungi, bacteria, nematodes and viruses.1 The benzimidazole ring is included in biologically active substances and in a variety of clinically useful drugs such as Omeprazole, Astemizole, Emedastine difumarate, and Cyanocobalamine.2 In particular, during the last decade, the antiallergic and antihistaminic activity of the benzimidazoles has received much ...
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In the title compound, C13H8ClFN2, the dihedral angle between the plane of the benzimidazole ring system (r.m.s. deviation = 0.022 Å) and the benzene ring is 26.90 (8)°. The F atom at the meta position of the benzene ring is disordered over two sites in a 0.843 (4):0.157 (4) ratio. In the crystal, mol-ecules are linked by N-H⋯N hydrogen bonds, forming infinite C(4) chains propagating along [010...
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The crystal structure of human chymase complexed with a novel benzimidazole inhibitor, TJK002, was determined at 2.8 Å resolution. The X-ray crystallographic study shows that the benzimidazole inhibitor forms a non-covalent interaction with the catalytic domain of human chymase. The hydrophobic fragment of the inhibitor occupies the S1 pocket. The carboxylic acid group of the inhibitor forms hy...
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biological activities,1 and some of them are used as drugs.2,3 In previous studies,4,5 we reported on the synthesis and biological evaluation of 1,2,5(6)-trisubstituted benzimidazoles as antihistaminic and antimicrobial agents. The synthesis of ethyl 1-cyclopropyl-5-fluoro-6-(4-methylpiperazine-1-yl)-1H-benzimidazole-2-acetate (1) was performed according to reported methods.6,7 1-Cyclopropyl-2-...
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A new Cu(II) complex of CuL(ClO4)2 (here, L = N,N,N 0,N 0-tetrakis[(2-benzimidazolyl)methyl]-1,3-diaminopropane) has been synthesized and characterized by elemental analyses, UV–Vis, FT-IR, cyclic voltammogram and X-ray single crystal diffraction. The Cu(II) environmental in complex is distorted octahedral. p–p stacking interactions stabilize the crystal packing together with the hydrogenbondin...
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ژورنال
عنوان ژورنال: Zeitschrift für Kristallographie - New Crystal Structures
سال: 1999
ISSN: 2197-4578,1433-7266
DOI: 10.1515/ncrs-1999-0220